"The humanitarian situation in Yemen is very difficult... (with) naval, air, and ground routes cut off," said the spokeswoman for the International Committee of the Red Cross in Yemen, Marie Claire Feghali.
She singled out Aden, where she described the situation as "catastrophic to say the least."
"The war in Aden is on every street, in every corner... Many are unable to escape," she said.
At least 18 people were killed in overnight fighting in the city, medical and security sources said. Another 53 were killed over the previous 24 hours.
The Red Cross has appealed for an immediate truce to facilitate aid deliveries.
It has called for land, air and sea routes to be opened to allow delivery of 48 tonnes of medical supplies it has ready to treat up to 3,000 wounded.
The Red Cross has been trying to fly emergency supplies into Sanaa but the plane is still stuck on the tarmac.
It is also trying to deploy a team of surgeons to Aden, but says it is still waiting for authorisations from the opposing sides.
"The priority for the Red Cross right now is for hospitals to continue to operate and to save the lives of as many people as possible," Feghali said.
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